The Trouble with “Brain Boosting” Vitamins

This post is a response to the article “The Vitamin Myth: Why We Think We Need Supplements” written by Paul Offit in 2013.

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Vitamins perform a vast number of functions in the body from aiding in growth and digestion to even nerve function. The National Institute of Health estimates that more than one third of all Americans take a multivitamin daily and virtually every vitamin needed by the body can be consumed in pills or gummies. Though vitamins are supposed to be consumed in a balanced diet, supplements have gained a lot of momentum in the health industry as people believe certain vitamin supplements can benefit their wellness or cure ailments. Claims in particular about vitamin C in the past have been exaggerated by reputable scientists and exacerbated by the media.

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In “The Vitamin Myth”, Paul Offit describes a phenomenon of pseudoscience spreading like wildfire around the United States after the Nobel Prize winning Linus Pauling began to make claims of curing diseases and extending life expectancy as a result of increasing vitamin C intake. Offit introduces Pauling by his many accomplishments and awards that catapulted him to his fame as “the most outstanding young chemist in the United States” (pg. 2). “In 1961, he appeared on the cover of Time magazine’s Men of the Year issue, hailed as one of the greatest scientists who had ever lived,” (pg. 3) Offit cites. But apart from his discoveries of electron sharing as a molecular bonding tool, sickle hemoglobin’s reaction with oxygen, the secondary structure of proteins, and the date of evolutionary divergence of humans from gorillas, he was also known as a worldwide peace activist. Offit lists that he “opposed the internment of Japanese Americans during WWII, … opposed nuclear proliferation, publicly debated nuclear arms hawks like Edward Teller, forced the government to admit that nuclear explosions could damage human genes, convinced other Nobel Prize winners to oppose the Vietnam War” (pg. 3) and for his efforts won the Nobel Peace Prize in 1962.

Then at the age of 65 his career took a dramatic turn for the worst after Pauling touted the miraculous health benefits of outrageous amounts of vitamin C. He urged the public to take thousands of milligrams of vitamins to cure basically any issue although many studies showed that there were no benefits to excessive use of vitamin supplements. He lost his great reputation in the scientific community after his obsession proved to be more harmful than anything. After his death, the research of the early 2000’s provided ample evidence that there was actually a reported increase in mortality for at risk people who took supplements.

Time USA, April 6, 1992

The accomplishments of Pauling were so numerous it was startling to read just how drastic his fall from fame was. Linus Pauling is mostly remembered for his obsession with the medical benefits of vitamins, but had he looked into the research that was presented to him he would have likely agreed with their methods and results, and his reputation today would probably had been preserved. His overconfidence was likely based on a need for this research to be significant and the personal bias caused by the placebo effect. The energy and health benefits he claimed to experience firsthand could be attributed to his overwhelming confidence that the vitamins would work.

The outrage Pauling showed at the findings of Charles Moertel, of the Mayo Clinic, proves his intense personal bias for this unfounded research. Offit recognizes Pauling’s initial rebuttle that the Mayo Clinic only “treated patients who had already received chemotherapy” (pg. 6) as the issue with their study. Yet when Moertel conducted a second study with the same results, Pauling felt it was a “personal attack on his integrity” (pg. 6) and tried to sue. This seems, to readers, like such an unnecessary overreaction to this report it makes the chemist’s mental state appear fragile and unstable.

It is so ironic that Offit notes Pauling saying there was no side effects to long term use of large quantities of vitamin C and then stating seven months later his wife died of stomach cancer (pg. 10). It should have been the ultimate event for a realization of his faults, and yet he stuck to his claims until he himself died of prostate cancer a few years later. Consistently it has been shown that vitamin C doesn’t treat cancer and doesn’t cure any of the many ailments people can get.

Vogue Archives, 1971, Interview by Leticia Kent

The National Institute of Health supports that clinical deficiencies of vitamins can disrupt cognition, but an excess of vitamins will not improve brain functioning in the normal person. The market is flooded with supplements promising to improve memory or “boost” brain function; remember vitamin supplements are only beneficial to people that have vitamin deficiencies.

101

I never wanted to change the world or be remembered. Growing up I thought there would always be someone better than me to try to pose solutions to global needs like fair politics, climate change, and the ever elusive “Cure for Cancer”. My parents held high expectations of me, and as report cards maintained remarkable grades over the years, my family came to expect that I would be in business, or go to law school, and make a name of myself. I never wanted to be a doctor until my sophomore year of high school. I was enthralled with my introductory psychology class because of the nervous system and the complex way that it worked to organize our bodies, thoughts, and responses. I found my passion as a sixteen year old flipping through, and trying to memorize, the pages of The Brain Facts Book after choir rehearsal.  

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Naturally, when the school year ended and the work was over, I expressed that I wanted to continue learning at the University of Miami for my summer vacation. It was unorthodox for a rising senior to be spending the time to travel and relax instead back inside a classroom for a summer STEM program, but I knew it was where I needed to be. I studied more on the mechanism of sending a message through neurons; how dendrites would receive the message chemically, send it down the axon shaft electrically, and then trigger a release of chemicals to the next neuron. But more importantly, that summer I was  first introduced to glial cells. Glial cells are supporting cells for the neurons in the nervous system. They are much more numerous than the 86 billion neurons that make up the average human, and scientists are pioneering research now that recognizes the critical importance of glial cells in regulating neuronal function.  

There are three main types of glial cells in the Central Nervous System: astrocytes, microglia, and oligodendrocytes. Astrocytes, pictured to the right in green, are star-shaped cells that transport nutrients to the neuron, protect the brain from toxic blood vessel contact, and regulate excessive excitatory transmissions between neurons. Microglia, illustrated in red, are the fastest moving cells in the brain which allows them to completely scan the brain for danger every couple hours for issues such as debris or damage, and fight back with phagocytosis (ejection). Oligodendrocytes, depicted as blue  attachments, are cells that produce a coating called myelin. This coating insulates, protects, and speeds transmission of electrical messages just like electrical wires covered with rubber preserve the voltage inside the circuit. When that myelin falls apart, it’s like a phone charger with a torn wire that must be kept in the one position that keeps charging.

When your charger breaks, it’s annoying, but it’s not the end of the world; just run to the store or even your house junk drawer to find a replacement. But things aren’t that simple with repairing brain and spinal glial cells. People with Multiple Sclerosis, a degenerative disease, have T-cells attacking their myelin, exposing their neurons to  damage, and causing an eventual slowing, or stopping, of transmissions between neurons. This leads to symptoms such as numbness, spastic muscles, weakness, fatigue, vision problems, and difficulty walking because the normal signals that  would be sent quickly and uninterrupted, now are tedious and choppy. 

Not even one process in the brain can be conducted without the help and regulation of glial cells, yet understanding the billions of glial cells in the body and their interactions with neurons is just recently being regarded as important to unravel. I’m fascinated with the immense, slightly overwhelming amount of complexity within the nervous system, and I want to learn more. 

I never wanted to change the world. I wanted to discover it. 

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